SIRP beta 1B Products

Description

Signal-regulatory protein beta 1b (SIRP beta 1b), or CD172b, is a disulfide-linked type I membrane glycoprotein belonging to the SIRP/SHPS/CD172 family of the immunoglobulin (Ig) superfamily. The three SIRP family members are paired receptors that have a conserved extracellular domain (ECD) but differing C-terminal domains and functions (1). The ECD of SIRP beta 1b contains one V-set Ig and two C1-set Ig domains. The mature ECD of mouse SIRP beta 1b shares 57% amino acid sequence identity with human SIRP beta 1. Proteins in the SIRP family are typically expressed in cells of monocyte, macrophage or dendritic lineages and positively charged residues within the transmembrane domain mediate interactions with DAP12 proteins which contain immunoreceptor tyrosine-based activation motifs (ITAMs) (3, 4). SIRP beta 1 has a relatively short cytoplasmic region and lacks the signaling motifs for association with phosphatases. However, formation of the SIRP beta 1/DAP12 complex in myeloid cells induces tyrosine phosphorylation, mitogen-activated protein kinase activation, and cellular activation (5, 6). Engagement of SIRP beta 1 by specific monoclonal antibodies promoted Fc gamma receptor-dependent or - independent phagocytosis in mouse peritoneal macrophages (7). Surfactant protein D (Sp-D) has been shown to bind SIRP alpha and SIRP beta 1 in a calcium-dependent and sugar-specific manner on a distinct binding site from CD47 (8). Although the SIRP beta 1 extracellular regions share a high degree of homology with the SIRP alpha, SIRP beta 1 has been shown not to bind CD47 (9).

Bioinformatics