Description
Surfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular head regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
100288405 |
| Alternate Names |
- COLEC4
- COLEC6
- MGC133365
- PSAP
- PSPA
- Pulmonary surfactant apoprotein
- Pulmonary surfactant associated protein
- SFTP1
- SFTPA1
- SFTPA3P surfactant protein A3, pseudogene
- SFTPAP1
- SFTPP1
- SP A
- SP A1
- Surfactant pulmonary associated protein A1
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