Selenoprotein W Products

Antibodies
Selenoprotein W Antibody
Selenoprotein W Antibody
NBP1-49599
Species: Hu, Mu, Rt
Applications: WB, ELISA, IP
Host: Rabbit Polyclonal
Lysates
Selenoprotein W Overexpressio ...
Selenoprotein W Overexpression Lys...
NBP2-10861
Applications: WB
Proteins
Selenoprotein W Recombinant P ...
Selenoprotein W Recombinant Protein
NBP2-51825
Species: Hu
Applications: PAGE

Description

The function of Selenoprotein W is not entirely known, but the presence of the bound glutathione moiety indicates that SEPW1 is thought to function in oxidation-reduction catalysis and may play a role in selenium deficiency disorders such as white muscle disease in sheep and Keshan disease in humans. Recently, overexpression of SEPW1 was shown to be glutathione dependent and was shown to markedly reduce the sensitivity of cell lines to H2O2 cytotoxicity. Selenoprotein W encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 6415
Alternate Names
  • selenoprotein W
  • selW
  • SELW
  • selenoprotein W, 1

PTMs for Selenoprotein W

Learn more about PTMs related to Selenoprotein W.

Phosphorylation
Reduction
Ubiquitination
Methylation

Bioinformatics Tool for Selenoprotein W

Discover related pathways, diseases and genes to Selenoprotein W. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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