Saccharomyces Cerevisiae Products

Description

Recombinant human Sialate O-acetylesterase (SIAE) is a glycosylated lysosomal protein that has two transcript isoforms: the cytosolic sialic acid esterase (Cse) that lacks 35 amino acids at the N-terminus and the lysosomal/membrane-associated sialic acid esterase (Lse) (1, 2). The Lse form is the predominantly expressed form responsible for the acetyl esterase activity on NeuAc in most tissues (2) and represents the recombinant product form. SIAE contains a signal sequence, a variable N-terminus, and a core protein structure that is unique within the SGNH hydrolase family (2) and contains a shallow active site pocket that accommodates binding of various complex substrates with acetylated sialic acid. SIAE Lse form catalyzes the removal of O-acetyl ester groups from position 9 of Sialic acid and is highly expressed in the testis, colon, and prostrate (3). SIAE deficiency has been shown to impact B cell development, signaling, and immunological tolerance through modulation of Siglec binding (4). Many SIAE variants in humans that result in defective activity or improper secretion have been identified in patients with autoimmune diseases including Crohn's disease, Sjogren's syndrome, lupus, rheumatoid arthritis, and type I diabetes (5). In addition, SIAE modulation of Siglec binding and sialic acid levels may play a key role in the immune evasion pathway associated with cancer (6). SIAE has also been implicated to play an important role in immune modulation during pregnancy (7). 

Bioinformatics

Uniprot	Q9HAT2
Alternate Names	AIS6 Bakers yeast Baker's yeast Bakers' yeast Brewers yeast Brewer's yeast Brewers' yeast CSEC CSE-C EC 3.1.1.53 LSE MGC87009 S cerevisiae S. cerevisiae S.cerevisiae SIAE Sialate O-Acetylesterase YSG2