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RPL15, also known as Ribosomal Protein L15 or RPL10, has a 204 amino acid long isoform that is 24kDa, and a shorter 145 amino acid long isoform that is approximately 17kDa. RPL15 is a cytoplasmic protein that is component of the large 60S subunit of the ribosome. In some esophageal tumors, RPL15 has been found to be overexpressed. Current research on RPL14 has shown possible links with esophageal cancer, thyroid cancer, Diamond-Blackfan anemia and gastric cancer. RPL15 has also been shown to interact with HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D and HIST1H4E.
