Ricinus Communis Agglutinin 60 Products

Antibodies
Ricinus Communis Agglutinin 6 ...
Ricinus Communis Agglutinin 60 Ant...
NB110-17180
Species: Pl
Applications: WB, ELISA
Host: Mouse Monoclonal
Ricinus Communis Agglutinin 6 ...
Ricinus Communis Agglutinin 60 Ant...
NB110-17269
Species: Pl
Applications: WB, ELISA
Host: Mouse Monoclonal

Description

Ricinus communis agglutinin 60(RCA60) is an extremely toxic glycoprotein consisting of two disulfide-linked chains of about 28,000 daltons and 32,000 daltons, termed A and B chain, respectively. The B chain can bind to cell surfaces via galactose or N-acetylgalactosamine residues of membrane glycoconjugates and facilitates the transport of the lectin into the cell. The A chain has an enzyme activity which can catalytically block protein synthesis and is so toxic that only a single molecule of A chain is required to kill a cell. Alone, the A chain is incapable of entering the cell and is thus not toxic. The A chain can be separated from the B chain and then linked by a cleavable disulfide bond to other proteins, such as antibodies. These antibody-toxin hybrid molecules can be used to kill specific cells with the appropriate antigenic determinant exposed, such as tumor markers on surfaces of malignant cells.

Bioinformatics

Alternate Names
  • Agglutinin
  • Ricn
  • RCA60
  • RCA
  • Castor bean