RAS p21 Products

Antibodies
RAS p21 Antibody (B4F8)
RAS p21 Antibody (B4F8)
NB120-13057
Species: Hu, Mu, Rt, Bv, Ha
Applications: WB, ICC/IF, IP
Host: Mouse Monoclonal
RAS p21 Antibody (2C12)
RAS p21 Antibody (2C12)
H00005921-M01
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
RAS p21 Antibody (1E6)
RAS p21 Antibody (1E6)
H00005921-M03
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Antibody Pairs
RAS p21 Antibody Pair
RAS p21 Antibody Pair
H00005921-PW2
Species: Hu
Applications: WB, IP
Lysates
RAS p21 Overexpression Lysate ...
RAS p21 Overexpression Lysate (Den...
H00005921-T01
Species: Hu
Applications: WB
RAS p21 Overexpression Lysate ...
RAS p21 Overexpression Lysate (Nat...
NBL1-15164
Applications: WB
Proteins
RAS p21 Recombinant Protein
RAS p21 Recombinant Protein
H00005921-P01
Species: Hu
Applications: WB, ELISA, PA
RAS p21 Partial Recombinant P ...
RAS p21 Partial Recombinant Protein
H00005921-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
RAS p21 RNAi
RAS p21 RNAi
H00005921-R02
Species: Hu
RAS p21 RNAi
RAS p21 RNAi
H00005921-R01
Species: Hu

Description

RasGAP, a regulator of Ras and Rho, stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. RasGAP is a Caspase 3 substrate (1) and acts as both pro- and anti-apoptotic protein depending on the extent of its cleavage by caspases (2). At low levels of caspase activity, RasGAP is cleaved at position 455, generating an N-terminal fragment (fragment N) and a C-terminal fragment (fragment C). Fragment C alone can induce apoptosis, but this response is completely inhibited by fragment N (3). Fragment N appears to be a general blocker of apoptosis downstream of caspase activation because it inhibits caspase 9-induced cell death. At higher caspase activity, fragment N is further processed and Cleavage of fragment N abrogates its protective functions, and hence the second cleavage of RasGAP promotes apoptosis (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5921
Alternate Names
  • PKWS
  • Ras p21 protein activator
  • CMAVM
  • RasGAP
  • GTPase-activating protein
  • triphosphatase-activating protein
  • RASA
  • ras GTPase-activating protein 1
  • p120RASGAP
  • RASGAP
  • GAPp120GAPCM-AVM
  • DKFZp434N071
  • RAS p21 protein activator (GTPase activating protein) 1

Research Areas for RAS p21

Find related products by research area and learn more about each of the different research areas below.

Cancer
Core ESC-Like Genes
Neuronal Cell Markers
Neuroscience
Phospho-Specific
Signal Transduction
Stem Cell Markers

PTMs for RAS p21

Learn more about PTMs related to RAS p21.

Phosphorylation

Bioinformatics Tool for RAS p21

Discover related pathways, diseases and genes to RAS p21. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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