RAP1GAP Products

Description

Rap1GAP, an 85/95kDa protein, is a member of a family of GAP's specific for Rap1 (1). Though to be an important tumor suppressor, Rap1GAP has no sequence homology with other GAPs such as RasGAP, RanGAP and RhoGAP. Purified as a cytosolic and membrane-bound protein, both isoforms consist of two monomers each contain a dimerization and a catalytic domain (2-4). Mutations in the GAP domain of the tumor suppressor tuberin, can cause benign tumor phenotype tuberous sclerosis (5).

Bioinformatics

Entrez	110351 Mouse 298570 Rat 5909 Human
Uniprot	AAH54490 Human AAH54490.1 Human NP_002876 Human P47736 Human
Product By Gene ID	5909
Alternate Names	GTPase activating protein 1 RAP1 GTPase activating protein

Research Areas for RAP1GAP

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Cellular Markers
Lysosome Markers