Protein Phosphatase inhibitor 1 Products

Antibodies
Protein Phosphatase inhibitor ...
Protein Phosphatase inhibitor 1 An...
NBP2-24490
Species: Hu, Ca, Eq, Pm, Bovine, Mouse, Rat, Xenopus
Applications: WB, IHC-P
Host: Rabbit Polyclonal
Protein Phosphatase inhibitor ...
Protein Phosphatase inhibitor 1 An...
NBP2-37895
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Protein Phosphatase inhibitor ...
Protein Phosphatase inhibitor 1 Ov...
NBL1-14678
Applications: WB
Proteins
Protein Phosphatase inhibitor ...
Protein Phosphatase inhibitor 1 Re...
H00005502-P01
Species: Hu
Applications: WB, ELISA, PA
Protein Phosphatase inhibitor ...
Protein Phosphatase inhibitor 1 Re...
NBP2-37895PEP
Species: Hu
Applications: AC

Description

The inhibitor of protein phosphatase 1 (IPP-1, I-1) is an endogenous inhibitor of protein phophastase 1 (PP-1), a signal transducer in many cellular pathways. IPP-1 is a member of heat-stable PP1 inhibitory subunits, which includes DARPP-32, (a homologue of IPP-1) and IPP-2. First discovered in rabbit skeletal muscle, IPP-1 is expressed in various mammalian tissues. IPP-1 inhibition of PP-1 is controlled through phosphorylation at Thr35 by cAMP-dependent protein kinase and a tetra-peptide consensus motif in various PP-1 binding proteins (1). IPP-1 is a hormonal control in muscle contraction, pituitary cell growth, synaptic plasticity by neurotransmitters, and glycogen metabolism (2). In vivo, IPP-1 is phosphorylated at Ser-67 by NCLK, which also initiates inhibition of PP-1 by IPP-1 (3). Triggered by increase in calcium level, IPP-1 is inactivated by PP2B through de-phosphorylation (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 5502
Alternate Names
  • IPP-1
  • protein phosphatase inhibitor-1
  • I-1
  • protein phosphatase 1 regulatory subunit 1A
  • Protein phosphatase inhibitor 1
  • IPP1inhibitor-1
  • I1
  • protein phosphatase 1, regulatory (inhibitor) subunit 1A

Pathways for Protein Phosphatase inhibitor 1

View related products by pathway and learn more about each of the pathways below.

Mitosis
Localization
Glycolysis

Bioinformatics Tool for Protein Phosphatase inhibitor 1

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