Species: Hu, Mu, Rt, Ca, Eq, Pm, Bv, Xp
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Species: Hu
Applications: AC
Description
The inhibitor of protein phosphatase 1 (IPP-1, I-1) is an endogenous inhibitor of protein phophastase 1 (PP-1), a signal transducer in many cellular pathways. IPP-1 is a member of heat-stable PP1 inhibitory subunits, which includes DARPP-32, (a homologue of IPP-1) and IPP-2. First discovered in rabbit skeletal muscle, IPP-1 is expressed in various mammalian tissues. IPP-1 inhibition of PP-1 is controlled through phosphorylation at Thr35 by cAMP-dependent protein kinase and a tetra-peptide consensus motif in various PP-1 binding proteins (1). IPP-1 is a hormonal control in muscle contraction, pituitary cell growth, synaptic plasticity by neurotransmitters, and glycogen metabolism (2). In vivo, IPP-1 is phosphorylated at Ser-67 by NCLK, which also initiates inhibition of PP-1 by IPP-1 (3). Triggered by increase in calcium level, IPP-1 is inactivated by PP2B through de-phosphorylation (4).
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
5502 |
| Alternate Names |
- I1
- I-1
- IPP-1
- IPP1inhibitor-1
- protein phosphatase 1 regulatory subunit 1A
- protein phosphatase 1, regulatory (inhibitor) subunit 1A
- Protein phosphatase inhibitor 1
- protein phosphatase inhibitor-1
|
Pathways for Protein Phosphatase inhibitor 1
View related products by pathway and learn more about each of the pathways below.
MitosisLocalizationGlycolysis
Bioinformatics Tool for Protein Phosphatase inhibitor 1
Discover related pathways, diseases and genes to Protein Phosphatase inhibitor 1. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.
-Western-Blot-NBL1-14678-img0002.jpg)
