PRDM8 Products

Antibodies
PRDM8 Antibody
PRDM8 Antibody
NBP1-33646
Species: Hu, Mouse
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
RNAi
PRDM8 RNAi
PRDM8 RNAi
H00056978-R01
Species: Hu

Description

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger gene RIZ 1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ 1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ 1 is also a tumor susceptibility gene in mice. The loss of RIZ 1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ 1 promoter strongly correlated with lost or decreased RIZ 1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

Bioinformatics

Entrez Human
Product By Gene ID 56978
Alternate Names
  • PR-domain containing protein 8
  • PR domain-containing protein 8
  • PR domain zinc finger protein 8
  • PFM5
  • PR domain containing 8

Pathways for PRDM8

View related products by pathway and learn more about each of the pathways below.

Cell Proliferation
System Development
Cell Cycle
Nervous System Development
Cell Differentiation
Neurogenesis

Research Areas for PRDM8

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research

PTMs for PRDM8

Learn more about PTMs related to PRDM8.

Methylation

Bioinformatics Tool for PRDM8

Discover related pathways, diseases and genes to PRDM8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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