PRDM10 Products

Description

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger gene RIZ 1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ 1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ 1 is also a tumor susceptibility gene in mice. The loss of RIZ 1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ 1 promoter strongly correlated with lost or decreased RIZ 1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

Bioinformatics

Entrez	56980 Human
Uniprot	NM_199437 Human NP_064613 Human Q9NQV6 Human
Product By Gene ID	56980
Alternate Names	KIAA1231PRDM zinc finger transcription factor MGC131802 PFM7tristanin PR domain containing 10 PR domain zinc finger protein 10 PR domain-containing protein 10 PR-domain family member 7 TRIS Tristanin

Research Areas for PRDM10

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research