Plasmacytoid Dendritic Cell Products

Description

Plasmacytoid Dendritic Cells (pDC) are a subset of peripheral blood Dendritic Cells which play an important role in both innate and adaptive immune responses. pDC recognize viral components via Toll-like Receptors (TLR) including TLR7 and TLR9, and then rapidly produce Interferon-alpha (IFNalpha) as a primary anti-viral immune response. pDC also participate in antigen presentation, an important functional role which drives the adaptive immune response. Intense investigation has led to pDC identifi cation with a unique set of markers by fl ow cytometry. pDC are usually present in relatively low frequency in peripheral blood. Direct identifi cation of subsets of peripheral blood DCs has an advantage in analyzing changes in number or function of DC subsets during chronic viral infections or diseased patients, as examples.

Bioinformatics

Alternate Names

Human Plasmacytoid Dendritic Cell (pDC) Human Plasmacytoid Dendritic Cell Plasmacytoid Dendritic Cell (pDC)