PKC eta Products

Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.

Bioinformatics

Entrez	5583 Human
Uniprot	AAH01000 Human NM_006255 Human NP_006246 Human NP_006246.2 Human P24723 Human
Product By Gene ID	5583
Alternate Names	EC 2.7.11 EC 2.7.11.13 nPKC-eta PKCLMGC26269 PKC-LMGC5363 PRKCLprotein kinase C eta type protein kinase C, eta

Research Areas for PKC eta

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction