PIP2 Products

Description

Metabolism of inositol phospholipids by intracellular signaling mediators is fundamental to signal transduction in eukaryotic cells. PI-4,5-P2 (PIP2) can be synthesized by phosphorylation of PI-4-P by type I phosphatidylinositol phosphate kinase (PIP5K I), or phosphorylation of PI-5-P by type II PIPK (PIP4K II). PI-4,5-P2 regulation of cellular calcium levels involves its hydrolysis by Phospholipase C (PLC) to produce inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), which serve as second messengers in the import of calcium via IP3-sensitive ion channels and in the activation of PKC, respectively.

Bioinformatics

Alternate Names

1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol 4,5-bisphosphate) Phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol biphosphate Phosphatidylinositol diphosphate PIP 2

Research Areas for PIP2

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Signal Transduction