PIDD Products

Description

The protein encoded by the LRDD gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq)

Bioinformatics

Entrez	55367 Human
Uniprot	NM_145887 Human Q9HB75-3 Human
Product By Gene ID	55367
Alternate Names	leucine-rich repeat and death domain-containing protein leucine-rich repeats and death domain containing MGC16925 p53-induced protein with a death domain PIDD