PDF Products

Antibodies
PDF Antibody (3F3)
PDF Antibody (3F3)
NBP2-00814
Species: Hu
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
PDF Antibody
PDF Antibody
NBP2-38993
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
PDF Antibody
PDF Antibody
H00064146-B01P
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
Lysates
PDF Overexpression Lysate (Na ...
PDF Overexpression Lysate (Native)
NBL1-14234
Applications: WB
PDF Overexpression Lysate (De ...
PDF Overexpression Lysate (Denatured)
H00064146-T01
Applications: WB
Proteins
PDF Recombinant Protein Antig ...
PDF Recombinant Protein Antigen
NBP2-38993PEP
Species: Hu
Applications: AC
RNAi
PDF RNAi
PDF RNAi
H00064146-R01
Species: Hu

Description

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq]

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 64146
Alternate Names
  • EC 3.5.1.88
  • PLAB
  • peptide deformylase-like protein
  • MIC1
  • peptide deformylase, mitochondrial
  • GDF15
  • Polypeptide deformylase
  • PDF1A
  • peptide deformylase (mitochondrial)

Bioinformatics Tool for PDF

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