PCDHGB6 Products

Description

PCDHGB6 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq]

Bioinformatics

Uniprot	NP_061749 Human NP_115271.1 Human
Product By Gene ID	56100
Alternate Names	PCDH-gamma-B6 protocadherin gamma-B6 PCDH-GAMMA-B6 protocadherin gamma subfamily B, 6

Diseases related to PCDHGB6

Discover more about diseases related to PCDHGB6.

Malignant Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Epithelioma
Neoplasms

Pathways for PCDHGB6

View related products by pathway and learn more about each of the pathways below.

Methylation
Cell Proliferation
Gene Silencing
Dna Methylation

PTMs for PCDHGB6

Learn more about PTMs related to PCDHGB6.

Methylation

Bioinformatics Tool for PCDHGB6

Discover related pathways, diseases and genes to PCDHGB6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.