PCDHGA5 Products

Description

PCDHGA5 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Bioinformatics

Uniprot	NP_061741 Human NP_114443 Human NP_114443.1 Human
Product By Gene ID	56110
Alternate Names	cadherin ME3 CDH-GAMMA-A5 ME3 MGC142020 PCDH-gamma-A5 PCDH-GAMMA-A5 protocadherin gamma subfamily A, 5 protocadherin gamma-A5

Research Areas for PCDHGA5

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Neuroscience