PCDHA10 Products

Description

PCDHA10 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Bioinformatics

Uniprot	A1L493 Human NP_061724 Human NP_114066 Human Q9Y5I2 Human Q9Y5I2-3 Human
Product By Gene ID	56139
Alternate Names	CNR8 CNRN8 CNRS8 CRNR8 KIAA0345-like 4 ortholog to mouse CNR8 PCDH-ALPHA10 PCDH-alpha-10 protocadherin alpha 10 protocadherin alpha-10