PANK1 Products

Description

The pantothenate kinase (PANK) gene family contains four members and encodes five functional isoforms. The PANK enzymes are key to the synthesis of coenzyme A (CoA) (1,2). CoA is used by around 4% of intracellular enzymes as a co-substrate. PANK1 is the key regulatory enzyme in the CoA biosynthetic pathway and plays similar roles in both bacterial and mammalian cells (3). PANK1 expression levels are high in liver, kidney, and heart tissues (4). Mutations in PANK1 have been linked to Hallervorden-Spatz syndrome, an autosomal recessive neurodegenerative disorder caused by excessive brain iron accumulation due to the defects in CoA synthesis (5). The activity of this enzyme has been measured with a phosphatase-coupled method (6).

Bioinformatics

Uniprot	Q8TE04.2
Product By Gene ID	53354
Alternate Names	EC 2.7.1.33 HPanK HPanK1 MGC24596 PANK PANK1 PANK1a PANK1b pantothenate kinase 1 pantothenate kinase Pantothenic acid kinase 1