Species: Hu, Mu, Rt, Po, Bv, Pm, Sh
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Mu
Applications: PAGE
Species: Hu
Applications: AC
Description
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).
Bioinformatics
| Uniprot |
Human
|
| Product By Gene ID |
6622 |
| Alternate Names |
- Lewy body) 4
- MGC110988
- non A-beta component of AD amyloid
- Non-A beta component of AD amyloid
- Non-A4 component of amyloid precursor
- non-A4 component of amyloid
- PARK4
- synuclein, alpha (non A4 component of amyloid precursor)
|
