Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).
|Product By Gene ID
- Non-A4 component of amyloid precursor
- non-A4 component of amyloid
- Non-A beta component of AD amyloid
- non A-beta component of AD amyloid
- Lewy body) 4
- synuclein, alpha (non A4 component of amyloid precursor)
Bioinformatics Tool for pan-Synuclein
Discover related pathways, diseases and genes to pan-Synuclein. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.