pan-Synuclein Products

Antibodies
pan-Synuclein Antibody
pan-Synuclein Antibody
NBP2-47338
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
pan-Synuclein Antibody
pan-Synuclein Antibody
NB100-91983
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
pan-Synuclein Recombinant Pro ...
pan-Synuclein Recombinant Protein ...
NBP2-47338PEP
Species: Hu
Applications: AC
pan-Synuclein Recombinant Pro ...
pan-Synuclein Recombinant Protein
NBP1-72278
Species: Mu
Applications: PAGE

Description

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).

Bioinformatics

Uniprot Human
Product By Gene ID 6622
Alternate Names
  • MGC110988
  • Non-A4 component of amyloid precursor
  • PARK4
  • non-A4 component of amyloid
  • Non-A beta component of AD amyloid
  • non A-beta component of AD amyloid
  • Lewy body) 4
  • synuclein, alpha (non A4 component of amyloid precursor)

Research Areas for pan-Synuclein

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Cell Biology
Cytoskeleton Markers
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Neurodegeneration
Neuroscience
Stem Cell Markers

Bioinformatics Tool for pan-Synuclein

Discover related pathways, diseases and genes to pan-Synuclein. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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