pan AKT Products

pan AKT Assay Kit
pan AKT Assay Kit
Species: Hu, Mu, Rt, Ma
Applications: WB, Func, IP


FUNCTION: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.; CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.; ENZYME REGULATION: Three specific sites, one in the kinase domain (Thr-308) and the two other ones in the C-terminal regulatory region (Ser-473 and Tyr-474), need to be phosphorylated for its full activation.; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane. Note: Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A.; TISSUE SPECIFICITY: Widely expressed. Low levels found in liver with slightly higher levels present in thymus and testis.


Product By Gene ID 207
Alternate Names
  • RAC-PK-alpha
  • EC 2.7.11
  • Proto-oncogene c-Akt
  • RAC-alpha serine/threonine-protein kinase
  • Protein kinase B
  • rac protein kinase alpha
  • AKT
  • PKBMGC99656
  • EC
  • v-akt murine thymoma viral oncogene homolog 1

Research Areas for pan AKT

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
mTOR Pathway
Neuronal Cell Markers
Signal Transduction

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