p38 Products

Antibodies
p38 [p Thr180, p Tyr182] Anti ...
p38 [p Thr180, p Tyr182] Antibody
NB500-138
Species: Hu, Mu, Rt, Bv, Ca, Ch, Pm, Ze
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
p38 Antibody (8G4D11)
p38 Antibody (8G4D11)
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, CyTOF-ready
Host: Mouse Monoclonal
p38 Antibody (9F12)
p38 Antibody (9F12)
NB110-96875
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, IP, ICC
Host: Mouse Monoclonal
Antibody Pairs
p38 Antibody Pair
p38 Antibody Pair
H00001432-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
p38 [p Tyr182, p Thr180] ELIS ...
p38 [p Tyr182, p Thr180] ELISA Kit...
KA2169
Species: Hu, Mu
p38 [p Tyr182, p Thr180] ELIS ...
p38 [p Tyr182, p Thr180] ELISA Kit...
KA2170
Species: Hu, Mu
Lysates
p38 Overexpression Lysate (De ...
p38 Overexpression Lysate (Denatured)
H00001432-T01
Species: Hu
Applications: WB
p38 Overexpression Lysate (Na ...
p38 Overexpression Lysate (Native)
NBL1-12874
Applications: WB
p38 Overexpression Lysate (Na ...
p38 Overexpression Lysate (Native)
NBL1-12873
Applications: WB
Proteins
Recombinant Human p38 Protein ...
Recombinant Human p38 Protein
H00001432-P02
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human p38 Protein ...
Recombinant Human p38 Protein
H00001432-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human p38 Protein ...
Recombinant Human p38 Protein
H00001432-Q02
Species: Hu
Applications: WB, ELISA, PA
RNAi
p38 RNAi
p38 RNAi
H00001432-R06
Species: Hu
Applications: RNAi, RNAi SP
p38 RNAi
p38 RNAi
H00001432-R05
Species: Hu
Applications: RNAi, RNAi SP
p38 RNAi
p38 RNAi
H00001432-R07
Species: Hu
Applications: RNAi, RNAi SP

Description

The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 alpha translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 1432
Alternate Names
  • EC 2.7.11
  • MAP kinase p38 alpha
  • MXI2
  • MAP kinase 14
  • stress-activated protein kinase 2A
  • CSAID-binding protein
  • p38alpha Exip
  • SAPK2A
  • p38ALPHA
  • CSPB1
  • p38 mitogen activated protein kinase
  • CSBP2
  • p38 MAP kinase
  • CSBP
  • cytokine suppressive inflammatory drug binding protein
  • Mitogen-activated protein kinase p38 alpha
  • Csaids binding protein
  • MAP kinase MXI2
  • RK
  • Cytokine suppressive inflammatory drug-binding protein
  • p38
  • PRKM15
  • EXIP
  • PRKM14
  • EC 2.7.11.24
  • Mxi2
  • CSBP1MAX-interacting protein 2
  • MAPK 14
  • mitogen-activated protein kinase 14

Research Areas for p38

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Immunology
Innate Immunity
MAP Kinase Signaling
Phospho-Specific
Protein Kinase
Signal Transduction

PTMs for p38

Learn more about PTMs related to p38.

Phosphorylation
Cleavage
Ubiquitination

Bioinformatics Tool for p38

Discover related pathways, diseases and genes to p38. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related p38 Blog Posts

Check out the latest blog posts on p38.
MAPK3/ERK1 - A signal transduction pathway with roles in development and disease
Mitogen-activated protein kinases (MAPKs) are important signaling proteins needed to transmit and relay extracellular stimuli and to illicit intracellular responses (1). The MAPK family of proteins are serine/threonine kinases that are able to phos...    Read more.
Read more p38 related blogs.