p16 Products

Proteins
Human p16 Protein
Human p16 Protein
NBP2-35199
Species: Hu
Applications: WB, Func, PAGE
Human p16 TAT Protein
Human p16 TAT Protein
NBP2-35200
Species: Hu
Applications: Func, PAGE
p16 Recombinant Protein
p16 Recombinant Protein
H00001029-P01
Species: Hu
Applications: WB, ELISA, PA

Description

CDKN2A/p16INK4a is a gene that codes for a widely expressed protein with four isoforms, measuring 156, 105, 116, and 167 amino acids in length with weights of approximately 17, 11, 12, and 18 kDa respectively. CDKN2A/p16INK4a functions as a negative regulator of the proliferation of cells, which then allows them to interact with cyclins D and to phosphorylate the retinoblastoma protein. Current studies are being done on several diseases and disorders related to this gene including Li-Fraumeni syndrome, malignant peripheral nerve sheath tumor, blastic plasmacytoid dendritic cell, acth-secreting pituitary adenoma, recessive dystrophic epidermolysis bullosa, marginal zone b-cell lymphoma, adult astrocytic tumor, melanoma, and squamous cell carcinoma. CDKN2A/p16INK4a has also been shown to have interactions with MDM2, ZNF420, EGR1, MYCN, and CDK6 in pathways such as the cell cycle, p53 signaling, mitochondrial apoptosis, HIF-1 Alpha, CRHR, pancreatic cancer, and glioma pathways.

Bioinformatics

Uniprot Human
Human
Product By Gene ID 1029
Alternate Names
  • p19Arf
  • p19ARF
  • p19
  • p16INK4A
  • p16INK4a
  • p16-INK4a
  • p16
  • p16-INK4
  • p14
  • p14ARF
  • INK4a
  • cyclin-dependent kinase inhibitor 2A
  • P16
  • cell cycle negative regulator beta
  • MTS-1
  • CDK4 inhibitor p16-INK4
  • CDKN2
  • TP16
  • Multiple tumor suppressor 1
  • P19ARF
  • Cyclin-dependent kinase 4 inhibitor A
  • P19
  • INK4
  • P16INK4A
  • ARF
  • MLMP16INK4
  • CMM2P16-INK4A
  • CDK4IP14ARF
  • MTS1P14
  • INK4A
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Research Areas for p16

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Cancer
Cell Cycle and Replication
DNA Repair
Hypoxia
MAP Kinase Signaling
Neuroscience
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for p16

Discover related pathways, diseases and genes to p16. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related p16 Blog Posts

Check out the latest blog posts on p16.
Ku70: The DNA's Mr. Fix-it
Ku70, known by several synonyms including X-ray repair cross-complementing, 5'-deoxyribose-5-phosphate lyase Ku70 protein 6, 70 kDa subunit of Ku antigen, XRCC6, and G22P1, is a 70 kDa protein that was shown to be involved in multiple cellular pathway...    Read more.
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