WB, Func, PAGE, Bioactivity
Applications: Func, PAGE, Bioactivity
Applications: WB, ELISA, PA, AP
CDKN2A/p16INK4a is a gene that codes for a widely expressed protein with four isoforms, measuring 156, 105, 116, and 167 amino acids in length with weights of approximately 17, 11, 12, and 18 kDa respectively. CDKN2A/p16INK4a functions as a negative regulator of the proliferation of cells, which then allows them to interact with cyclins D and to phosphorylate the retinoblastoma protein. Current studies are being done on several diseases and disorders related to this gene including Li-Fraumeni syndrome, malignant peripheral nerve sheath tumor, blastic plasmacytoid dendritic cell, acth-secreting pituitary adenoma, recessive dystrophic epidermolysis bullosa, marginal zone b-cell lymphoma, adult astrocytic tumor, melanoma, and squamous cell carcinoma. CDKN2A/p16INK4a has also been shown to have interactions with MDM2, ZNF420, EGR1, MYCN, and CDK6 in pathways such as the cell cycle, p53 signaling, mitochondrial apoptosis, HIF-1 Alpha, CRHR, pancreatic cancer, and glioma pathways.
|Product By Gene ID
- cyclin-dependent kinase inhibitor 2A
- cell cycle negative regulator beta
- CDK4 inhibitor p16-INK4
- Multiple tumor suppressor 1
- Cyclin-dependent kinase 4 inhibitor A
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Bioinformatics Tool for p16
Discover related pathways, diseases and genes to p16. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related p16 Blog Posts
Check out the latest blog posts on p16.
Read more p16 related blogs.
|Ku70: The DNA's Mr. Fix-it
Ku70, known by several synonyms including X-ray repair cross-complementing, 5'-deoxyribose-5-phosphate lyase Ku70 protein 6, 70 kDa subunit of Ku antigen, XRCC6, and G22P1, is a 70 kDa protein that was shown to be involved in multiple cellular pathway... Read more.