Species: Hu
Applications: WB, ELISA, IP
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK
Bioinformatics
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
23327 |
| Alternate Names |
- E3 ubiquitin-protein ligase NEDD4-like
- EC 6.3.2
- EC 6.3.2.-
- FLJ33870
- hNedd4-2
- KIAA0439ubiquitin-protein ligase NEDD4-like
- NEDD4.2
- Nedd4-2
- NEDD4-2
- NEDL3
- neural precursor cell expressed, developmentally down-regulated 4-like
- neural precursor cell expressed, developmentally down-regulated gene 4-like
- RSP5ubiquitin-protein ligase Rsp5
|
