MRPL40 Products

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq]

Bioinformatics

Product By Gene ID	64976
Alternate Names	FLJ41774 L40mt MGC9400 mitochondrial ribosomal protein L40 MRP-L22,39S ribosomal protein L40, mitochondrial MRP-L40 NLVCFURIM nuclear localization signal containing protein deleted in velocardiofacialsyndrome nuclear localization signal deleted in velocardiofacial syndrome Nuclear localization signal-containing protein deleted in velocardiofacialsyndrome Up-regulated in metastasis