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MMP28 (matrix metallopeptidase 28), can degrade casein and belongs to the MMP family which are part of the metzincin superfamily of proteases. This protein is regulated by interferon alpha, MAPK1, TNF and ethylenediaminetetraacetic acid and is involved in calcium, zinc, and metal ion binding. Studies are currently being performed on the relationship of MMP28 protein to arthritis, various types of carcinoma, encephalomyelitis and multiple sclerosis.