Species: Hu
Applications: WB, IHC, IP, ICC/IF
Host: Goat Polyclonal
Species: Hu
Applications: ELISA, IHC, CyTOF-ready, Flow
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IP, ELISA(Cap)
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Mu
Applications: Enzyme Activity
Species: Hu
Applications: WB
Description
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-8 (also designated neutrophil collagenase, PMNL collagenase or collagenase-2) degrades fibrillar collagen types I, II and III. Unlike other members of the MMP family, MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is highly expressed in the postpartum uterus, and it is thought to be involved in the postpartum involution of the uterus. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
|
| Product By Gene ID |
4317 |
| Alternate Names |
- CLG1HNC
- Collagenase 2
- EC 3.4.24
- EC 3.4.24.34
- matrix metallopeptidase 8 (neutrophil collagenase)
- matrix metalloproteinase 8 (neutrophil collagenase)
- Matrix metalloproteinase-8
- MMP8
- MMP-8
- neutrophil collagenase
- PMNL collagenase
- PMNL-CL
|
Research Areas for MMP-8
Find related products by research area and learn more about each of the different research areas below.
Cancer
![Immunohistochemistry MMP-8 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/MMP-8_AF908_Immunohistochemistry_9975.jpg)
![Immunocytochemistry MMP-8 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/MMP8_AF908_Immunocytochemistry__Immunofluorescence_17431.jpg)
![Immunohistochemistry MMP-8 Antibody (100608) [Unconjugated]](http://images.novusbio.com/fullsize2/MMP-8_MAB9081_Immunohistochemistry_7051.jpg)
![ELISA MMP-8 Antibody (100608) [Unconjugated]](http://images.novusbio.com/fullsize2/mab9081_human-mmp-8-mab-clone-100608-elisa-15202074737.jpg)
![Intracellular Staining by Flow Cytometry MMP-8 Antibody (100608) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab9081_human-mmp-8-mab-clone-100608-intracellular-staining-by-flow-cytometry-175202410738..jpg)
![Western Blot MMP-8 Antibody (100619) [Unconjugated]](http://images.novusbio.com/fullsize/mab908_human-mmp-8-mab-clone-100619-41202412505342.jpg)
![Sandwich ELISA MMP-8 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/MMP-8-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79543-img0001.jpg)
![N/A MMP-8 [Biotin]](http://images.novusbio.com/fullsize2/DATA_MMP8_DY908_ELISA_2258.jpg)
