MBD3 Products

Antibodies
Antibody Pairs
MBD3 Antibody Pair
MBD3 Antibody Pair
H00053615-PW2
Species: Hu
Applications: WB, IP
Lysates
MBD3 Overexpression Lysate (D ...
MBD3 Overexpression Lysate (Denatu...
H00053615-T01
Applications: WB
Proteins
MBD3 Recombinant Protein
MBD3 Recombinant Protein
NBP2-23231
Species: Hu
Applications: PAGE
RNAi
MBD3 RNAi
MBD3 RNAi
H00053615-R01
Species: Hu

Description

DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD) (4). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA (3). MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases (2). In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract (1).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 53615
Alternate Names
  • methyl-CpG-binding domain protein 3
  • Methyl-CpG-binding protein MBD3
  • methyl-CpG binding domain protein 3

Research Areas for MBD3

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research

Bioinformatics Tool for MBD3

Discover related pathways, diseases and genes to MBD3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.