LRRC7 Products

Description

In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B & 1C share a high degree of sequence homology while LAP 2 is distinct from the others.LAP 1A & B bind lamins A, C and B1, while LAP 2 binds lamin B1 only.In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.

Bioinformatics

Entrez	57554 Human 242274 Mouse 117284 Rat
Uniprot	Q96NW7 Human
Product By Gene ID	57554
Alternate Names	DKFZp686I1147 leucine rich repeat containing 7 MGC144918

Research Areas for LRRC7

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cytoskeleton Markers
Neuroscience
Signal Transduction