Species: Hu, Mu, Rt
Host: Rabbit Polyclonal
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading to Axin degradation and beta catenin stabilization.
|Product By Gene ID
- low-density lipoprotein receptor-related protein 5
- low density lipoprotein receptor-related protein 7
- osteoporosis pseudoglioma syndrome
- LRP7exudative vitreoretinopathy 1
- low density lipoprotein receptor-related protein 5
Bioinformatics Tool for LRP5/6
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|The role of Wnts in neuroinflammation
By Michalina Hanzel, PhDThe multifaceted roles of the Wnt family of glycoproteins have been extensively characterized throughout embryonic development and adult homeostasis. The highly conserved, cell- and tissue- s... Read more.