LRP5/6 Products

Description

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading to Axin degradation and beta catenin stabilization.

Bioinformatics

Entrez	16973 Mouse 4041 Human
Uniprot	O75197 Human
Product By Gene ID	4041
Alternate Names	BMND1OPTA1 EVR1 EVR4 HBM low density lipoprotein receptor-related protein 5 low density lipoprotein receptor-related protein 7 low-density lipoprotein receptor-related protein 5 LR3VBCH2 LRP-5 LRP7exudative vitreoretinopathy 1 OPPG OPS osteoporosis pseudoglioma syndrome

Research Areas for LRP5/6

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Stem Cell Signaling Pathway
Vision
Wnt Signaling Pathway

Related LRP5/6 Blog Posts

Check out the latest blog posts on LRP5/6.

The role of Wnts in neuroinflammation By Michalina Hanzel, PhDThe multifaceted roles of the Wnt family of glycoproteins have been extensively characterized throughout embryonic development and adult homeostasis. The highly conserved, cell- and tissue- s...    Read more.

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