Description
Lin-61 encodes a protein that contains four malignant brain tumor (MBT) repeats and is similar to the human and mouse lethal (3) malignant brain tumor 2 [L(3)MBT2] proteins; LIN-61 is predicted to function in a transcriptional regulatory complex that may play a role in transcriptional repression during development; loss of lin-61 activity via RNAi and mutation indicates that LIN-61 is required for: 1) genome stability in the soma and germline, and 2) postembryonic developmental processes such as vulval development, in which lin-61 acts as a class B synthetic multivulval (SynMuv) gene and as a candidate transcriptional repressor of genes such at mat-3; LIN-61 is broadly expressed throughout development, from the one-cell embryo through adulthood, and localizes to nuclei.
Bioinformatics
Research Areas for LIN-61
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modENCODE Antibodies
