Lamin B2 Products

Antibodies
Lamin B2 Antibody (144)
Lamin B2 Antibody (144)
NBP2-43834
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
Lamin B2 Antibody
Lamin B2 Antibody
NBP1-33205
Species: Hu, Mu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Lamin B2 Antibody (LN43)
Lamin B2 Antibody (LN43)
NBP1-97890
Species: Hu, Mu, Po, Fi, Xp
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr
Host: Mouse Monoclonal
Lysates
Lamin B2 Overexpression Lysat ...
Lamin B2 Overexpression Lysate (Na...
NBP2-05979
Applications: WB
Proteins
Lamin B2 Recombinant Protein ...
Lamin B2 Recombinant Protein Antigen
NBP2-49368PEP
Species: Hu
Applications: AC
Lamin B2 Recombinant Protein ...
Lamin B2 Recombinant Protein Antigen
NBP2-48882PEP
Species: Hu
Applications: AC

Description

An important part of the cell nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. Lamin A, Lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. Lamin B1 and Lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of a-helices and a carboxyterminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus. Besides interactions with the nuclear membrane and other intermediate filaments, lamins interact with the nuclear chromatin. Eukaryotic chromatin is organized into loops, which are attached to the nuclear matrix. This organization is thought to contribute to compaction of the chromatin and regulation of gene expression. Lamins, as part of the nuclear matrix, may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 84823
Alternate Names
  • lamin-B2
  • MGC2721
  • LMN2LAMB2
  • lamin B2

Bioinformatics Tool for Lamin B2

Discover related pathways, diseases and genes to Lamin B2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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