Lambda5/IGLL1 Products

Description

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	3543 Human
Uniprot	AAH12293 Human NP_064455 Human NP_064455.1 Human P15814 Human
Product By Gene ID	3543
Alternate Names	14.1 AGM2 CD179 antigen-like family member B CD179b antigen CD179b Ig lambda-5 IGL1 IGL5CD179B IGLJ14.1 IGLL IGO IGVPB immunoglobulin lambda-like polypeptide 1 immunoglobulin omega polypeptide chain Immunoglobulin omega polypeptide immunoglobulin-related 14.1 protein Immunoglobulin-related protein 14.1 lambda5 Pre-B lymphocyte-specific protein-2 VPREB2