KSV Cyclin D Products

Description

This protein was identified by the interaction with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.

Bioinformatics

Alternate Names

Kaposi's Sarcoma Virus Type D Cyclin

Research Areas for KSV Cyclin D

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Core ESC-Like Genes
mTOR Pathway
Stem Cell Markers
Wnt Signaling Pathway