KIR5.1 Products

Description

The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as KIR1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as KIR1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Down's syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas. The gene encoding human KIR5.1 maps to chromosome 17.

Bioinformatics

Entrez	29713 Rat 3773 Human
Uniprot	NP_061128 Human NP_733937 Human Q9NPI9 Human
Product By Gene ID	3773
Alternate Names	BIR9 Inward rectifier K(+) channel Kir5.1 inward rectifier K+ channel KIR5.1 inward rectifier potassium channel 16 KIR5.1 Kir5.1 MGC33717 Potassium channel, inwardly rectifying subfamily J member 16 potassium inwardly-rectifying channel, subfamily J, member 16