KIR2DS3 Products

KIR2DS3 Antibody
KIR2DS3 Antibody
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
KIR2DS3 Overexpression Lysate ...
KIR2DS3 Overexpression Lysate
Species: Hu
Applications: WB


Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq)


Entrez Human
Uniprot Human
Product By Gene ID 3808
Alternate Names
  • killer cell immunoglobulin-like receptor 2DS3
  • killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail3,MHC class I NK cell receptor
  • natural killer cell inhibitory receptor
  • Natural killer-associated transcript 7
  • NKAT-7
  • NKAT7nkat7

Pathways for KIR2DS3

View related products by pathway and learn more about each of the pathways below.

Cell Division
Cell Activation
Cytokine Production
Cell Proliferation
Immune Response
Donor Selection

PTMs for KIR2DS3

Learn more about PTMs related to KIR2DS3.


Bioinformatics Tool for KIR2DS3

Discover related pathways, diseases and genes to KIR2DS3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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