KIR2DS3 Products

Antibodies
KIR2DS3 Antibody
KIR2DS3 Antibody
H00003808-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
KIR2DS3 Overexpression Lysate ...
KIR2DS3 Overexpression Lysate (Nat...
NBL1-12303
Applications: WB
RNAi
KIR2DS3 RNAi
KIR2DS3 RNAi
H00003808-R02
Species: Hu

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq)

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 3808
Alternate Names
  • natural killer cell inhibitory receptor
  • NKAT-7
  • killer cell immunoglobulin-like receptor 2DS3
  • Natural killer-associated transcript 7
  • NKAT7nkat7
  • killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail3,MHC class I NK cell receptor

Pathways for KIR2DS3

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Cell Division
Cell Activation
Cytokine Production
Cell Proliferation
Aging
Glycosylation
Immune Response
Donor Selection

PTMs for KIR2DS3

Learn more about PTMs related to KIR2DS3.

Glycosylation
Citrullination

Bioinformatics Tool for KIR2DS3

Discover related pathways, diseases and genes to KIR2DS3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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