KIF1B Products

Description

The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. KIF1B is an amino-terminal-type motor protein that is ubiquitously expressed, with the most abundant levels in differentiated nerve cells. The human KIF1B gene maps to chromosome 1p36.2. Defects in axonal transport due to mutations at the KIF1B gene can underlie the human peripheral neuropathy phenotype. The mouse KIF1B gene generates an alternatively spliced transcript, which produces two isoforms, a 7.8 kb mRNA encoding a 130 kDa protein, and a 10 kb mRNA encoding a 204 kDa protein.

Bioinformatics

Entrez	16561 Mouse 20395 Mouse 23095 Human
Uniprot	AAH01415 Human CAC16629.1 Human NP_904325 Human O60333 Human
Product By Gene ID	23095
Alternate Names	CMT2 CMT2A CMT2A1 HMSNII KIAA0591FLJ23699 KIAA1448 kinesin family member 1B kinesin superfamily protein KIF1B kinesin-like protein KIF1B Klp KLP MGC134844 NBLST1

Diseases related to KIF1B

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Charcot-marie-tooth Disease
Neoplasms
Neuroblastoma
Sclerosis
Multiple Sclerosis
Malignant Neoplasms
Hepatitis B
Liver Carcinoma
Hepatitis
Carcinoma
Nervousness
Peripheral Neuropathy
Hepatitis, Chronic
Hepatitis B, Chronic
Nerve Degeneration
Liver Neoplasms
Inherited Neuropathy
Cell Transformation, Neoplastic

Pathways for KIF1B

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Transport
Pathogenesis
Localization
Cell Proliferation
Vesicle Transport
Myelination
Methylation
Cell Division
Cell Death
Intracellular Transport
Dna Hypermethylation
Synaptic Transmission
Neurogenesis
Muscle Atrophy
Chromosome Segregation
Rna Splicing
Mitochondrial Fusion
Regeneration
Reverse Transcription
Cell Cycle

Research Areas for KIF1B

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Stem Cell Markers

PTMs for KIF1B

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Methylation
Acetylation

Bioinformatics Tool for KIF1B

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