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K15 (a putative transmembrane protein similar to LMP2A) Products

Antibodies

Description

Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.

Research Areas for K15 (a putative transmembrane protein similar to LMP2A)

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Virology, Bacteria and Parasites