JunD Products

Description

The activator protein-1 (AP-1) transcription factor consists of either Jun/Jun homodimers or Fos/Jun heterodimeric complexes. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family. Studies suggest that the two forms of Jun D may be due to internal initiation of translation.

Bioinformatics

Entrez	16478 Mouse 24518 Rat 3727 Human
Uniprot	NP_005345 Human P17535 Human
Product By Gene ID	3727
Alternate Names	activator protein 1 AP-1 jun D proto-oncogene JunD-FL isoform transcription factor jun-D

Research Areas for JunD

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Phospho-Specific