JunD Products

Description

The activator protein-1 (AP-1) transcription factor consists of either Jun/Jun homodimers or Fos/Jun heterodimeric complexes. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family. Studies suggest that the two forms of Jun D may be due to internal initiation of translation.

Bioinformatics

Entrez	3727 Human 16478 Mouse 24518 Rat
Uniprot	P17535 Human NP_005345 Human
Product By Gene ID	3727
Alternate Names	transcription factor jun-D JunD-FL isoform activator protein 1 AP-1 jun D proto-oncogene

Diseases related to JunD

Discover more about diseases related to JunD.

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Leukemia
Lymphoma
Endocrine Gland Neoplasms
Adult T-cell Lymphoma/leukemia
Skin Neoplasms
Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia
Neoplasm Metastasis
Leukemia, T-cell
Carcinoma
Injury To Liver
Fibrosis
Mammary Neoplasms
Inflammation
Colonic Neoplasms
Lymphoma, T-cell, Cutaneous
Tumor Angiogenesis

Pathways for JunD

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Cell Proliferation
Cell Cycle
Cell Death
Cell Growth
Programmed Cell Death
Hepatocyte Proliferation
Inflammatory Response
Translation
Regeneration
Angiogenesis
Rna Processing
Cell Adhesion
Cell Migration
Osteoblast Differentiation
Sertoli Cell Proliferation
Cellular Senescence
Cytokine Secretion
Immune Response
Fibroblast Proliferation
Hypersensitivity

Research Areas for JunD

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Phospho-Specific

PTMs for JunD

Learn more about PTMs related to JunD.

Phosphorylation
Acetylation

Bioinformatics Tool for JunD

Discover related pathways, diseases and genes to JunD. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.