JNK1/2 Products

Description

JNK (c-Jun N-terminal Kinase), also referred to as Stress Activated Protein Kinase (SAPK), is one of the main mitogen-activated protein kinases (MAPKs) in mammals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2. JNK is activated by a variety of cellular signals including growth factors, inflammatory cytokines, and environmental stress. The JNK/SAPK signaling pathway involves sequential activation of MAPK kinase kinase (MEKK1), MAPK kinase 4 (MKK4) or MKK7, SAPK/JNK, and c-Jun. Full activation of JNK requires phosphorylation of a threonine and a tyrosine residue in the motif Thr-Pro-Tyr. MKK7 and MKK4 phosphorylate JNK at threonine 183 and tyrosine 185, respectively. The JNK pathway functions to modulate cell cycle, apoptotic and transcriptional responses to stress.

Bioinformatics

Entrez	5599 Human
Product By Gene ID	5599
Alternate Names	c-Jun N-terminal kinase 1 EC 2.7.11 EC 2.7.11.24 JNK1 alpha protein kinase JNK1 beta protein kinase JNK1JNK1A2 JNK-46 JUN N-terminal kinase MAP kinase 8 MAPK 8 mitogen-activated protein kinase 8 isoform JNK1 alpha1 mitogen-activated protein kinase 8 isoform JNK1 beta2 mitogen-activated protein kinase 8 PRKM8JNK protein kinase JNK1 SAPK1JNK21B1/2 Stress-activated protein kinase 1 Stress-activated protein kinase JNK1

Research Areas for JNK1/2

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Phospho-Specific
Wnt Signaling Pathway