JNK1/2 Products

JNK1/2 [p Tyr185, p Thr183] A ...
JNK1/2 [p Tyr185, p Thr183] Antibody
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal


JNK1 and JNK2 are the predominant forms of JNK. JNK (c-Jun N-terminal Kinase), also referred to as Stress Activated Protein Kinase (SAPK), is one of the main mitogen-activated protein kinases (MAPKs) in mammals. JNK is expressed as ten different isoforms due to differential mRNA splicing. JNK is activated by a variety of cellular signals including growth factors, inflammatory cytokines, and environmental stress. The JNK/SAPK signaling pathway involves sequential activation of MAPK kinase kinase (MEKK1), MAPK kinase 4 (MKK4) or MKK7, SAPK/JNK, and c-Jun. Full activation of JNK requires phosphorylation of a threonine and a tyrosine residue in the motif Thr-Pro-Tyr. MKK7 and MKK4 phosphorylate JNK at threonine 183 and tyrosine 185, respectively. The JNK pathway functions to modulate cell cycle, apoptotic and transcriptional responses to stress.


Entrez Human
Uniprot Human
Product By Gene ID 5599
Alternate Names
  • EC 2.7.11
  • MAPK 8
  • protein kinase JNK1
  • MAP kinase 8
  • mitogen-activated protein kinase 8 isoform JNK1 beta2
  • c-Jun N-terminal kinase 1
  • mitogen-activated protein kinase 8 isoform JNK1 alpha1
  • JNK-46
  • JUN N-terminal kinase
  • Stress-activated protein kinase JNK1
  • JNK1 beta protein kinase
  • Stress-activated protein kinase 1
  • JNK1 alpha protein kinase
  • SAPK1JNK21B1/2
  • JNK1JNK1A2
  • EC
  • mitogen-activated protein kinase 8

Research Areas for JNK1/2

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Wnt Signaling Pathway

PTMs for JNK1/2

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Bioinformatics Tool for JNK1/2

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