ITPK1 Products

Antibodies
ITPK1 Antibody
ITPK1 Antibody
H00003705-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Mouse Polyclonal
ITPK1 Antibody
ITPK1 Antibody
NBP1-32678
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
ITPK1 Antibody
ITPK1 Antibody
NBP2-48686
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Antibody Pairs
ITPK1 Antibody Pair
ITPK1 Antibody Pair
H00003705-PW1
Species: Hu
Applications: WB, IP
Lysates
ITPK1 Overexpression Lysate ( ...
ITPK1 Overexpression Lysate (Denat...
H00003705-T01
Species: Hu
Applications: WB
ITPK1 Overexpression Lysate ( ...
ITPK1 Overexpression Lysate (Native)
NBP2-09660
Applications: WB
ITPK1 Overexpression Lysate ( ...
ITPK1 Overexpression Lysate (Native)
NBL1-12087
Applications: WB
Proteins
ITPK1 Recombinant Protein Ant ...
ITPK1 Recombinant Protein Antigen
NBP2-48686PEP
Species: Hu
Applications: AC
ITPK1 Recombinant Protein
ITPK1 Recombinant Protein
NBP1-98867
Species: Hu
Applications: PAGE
RNAi
ITPK1 RNAi
ITPK1 RNAi
H00003705-R01V
Species: Hu
Applications: WB, RNAi SP
ITPK1 RNAi
ITPK1 RNAi
H00003705-R02
Species: Hu

Description

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 3705
Alternate Names
  • ITRPK1
  • EC 2.7.1.159
  • Ins(13,4)P(3) 5/6-kinase
  • EC 2.7.1.134
  • Inositol-triphosphate 5/6-kinase
  • inositol-tetrakisphosphate 1-kinase
  • Inositol 13,4-trisphosphate 5/6-kinase
  • inositol 13,4-trisphosphate 5/6 kinase
  • inositol 13,4-triphosphate 5/6 kinase

Pathways for ITPK1

View related products by pathway and learn more about each of the pathways below.

Secretion
Dna Repair
Endocytosis
Cell Volume Homeostasis
Pathogenesis
Exocytosis
Localization

PTMs for ITPK1

Learn more about PTMs related to ITPK1.

Phosphorylation
Deacetylation
Acetylation
Dephosphorylation

Bioinformatics Tool for ITPK1

Discover related pathways, diseases and genes to ITPK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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