Importin beta/KPNB1 Products

Description

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq]

Bioinformatics

Entrez	16211 Mouse 24917 Rat 3837 Human
Uniprot	NP_002256.2 Human Q14974 Human
Product By Gene ID	3837
Alternate Names	IMB1 Impnb importin 1 importin 90 importin beta-1 subunit importin subunit beta-1 Importin-90 importin-90 IPO1 IPOB karyopherin (importin) beta 1 Karyopherin subunit beta-1 MGC2155 MGC2156 MGC2157 NTF97Pore targeting complex 97 kDa subunit Nuclear factor p97 PTAC97

Research Areas for Importin beta/KPNB1

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones