IL1RAPL1 Products

Description

Interleukin 1 receptor accessory protein-like 1 (IL1RAPL1), also known as Oligophenin-4 (OPHN4) and three immunoglobulin domain containing IL-1 receptor-related 2 (TIGIRR-2) (1), is a member of the IL-1 receptor superfamily. IL1RAPL1 is a single pass type I membrane protein which contains an N-terminal signal peptide (aa 1-18 ), three extracellular immunoglobulin-like domains (aa 19-350), a transmembrane domain (aa 358-378 ), an intracellular Toll/IL-1R domain (aa 403-562), and a long C-terminal tail which interacts with multiple signaling molecules (aa 549-644 ) (2). High expression levels of IL1RAPL1 was found in post-natal hippocampus, and its expression is upregulated by neuronal activity (3). The extracellular domain of IL1RAPL1 can mediate synapse formation through trans-synaptic interaction with PTPRD (4, 5). In neurons, IL1RAPL1 interacts with PSD-95, a major scaffolding protein of excitatory synapses, and modulates its synaptic localization by regulating JNK activity and PSD-95 phosphorylation (3).  Mutation or deletion of IL1RAPL1 gene is associated with non-syndromic intellectual disability and autism spectrum disorder (5). Human IL1RAPL1 shares 98% and 99% aa sequence identity with mouse and rat IL1RAPL1, respectively.

Bioinformatics

Uniprot	NP_055086.1 Human
Product By Gene ID	11141
Alternate Names	IL1R8IL1RAPL IL-1R9 IL1RAPL1 IL-1RAPL1 IL-1-RAPL-1 IL-1RAPL-1 IL1RAPL-1 interleukin 1 receptor accessory protein-like 1 interleukin 1 receptor-8 interleukin-1 receptor accessory protein-like 1 mental retardation, X-linked 10 MRX10 MRX21 MRX34 Oligophrenin-4 OPHN4mental retardation, X-linked 21 Three immunoglobulin domain-containing IL-1 receptor-related 2 TIGIRR-2 TIGIRR-2mental retardation, X-linked 34 X-linked interleukin-1 receptor accessory protein-like 1