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MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0102B)." class="big_lightbox" target="_blank">
663-2R) is immobilized at 0.5 µg/mL (100 µL/well), in the presence of Recombinant Human IL-1 beta /IL-1F2 (201-LB), it binds to Biotinylated Recombinant Human IL-1 RAcP/IL-1 R3 Fc Chimera Avi-tag Protein (Catalog # AVI11139) with an ED50 of 4.00-36.0 ng/mL." class="big_lightbox" target="_blank">
11085-RI) is immobilized at 2 µg/mL (100 µL/well) in the presence of Recombinant Human IL‑1 beta /IL‑1F2 Protein (201-LB), it binds to Biotinylated Recombinant Human IL‑1 RAcP/IL‑1 R3 His-tag Avi-tag Protein (Catalog # AVI9176) with an ED50 of 50.0-400 ng/mL." class="big_lightbox" target="_blank">
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).
![Flow Cytometry IL-1 RAcP/IL-1 R3 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/af676_human-il-1-racp-il-1-r3-affinity-purified-polyclonal-ab-flow-cytometry-1520247473.jpg)
![N/A IL-1 RAcP/IL-1 R3 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IL1_RAcP_DY676_ELISA_2175.jpg)
![Binding Activity IL-1 RAcP/IL-1 R3 [Biotin]](http://images.novusbio.com/images/avi11139_recombinant-human-il-1-racp-il-1-r3-fc-avi-tag-protein-cf-binding-activity-275202211942.jpg)
![SDS-Page IL-1 RAcP/IL-1 R3 [Biotin]](http://images.novusbio.com/fullsize/avi11139_recombinant-human-il-1-racp-il-1-r3-fc-avi-tag-protein-cf-sds-page-2752022111853.jpg)
![Binding Activity IL-1 RAcP/IL-1 R3 [Biotin]](http://images.novusbio.com/images/avi9176_recombinant-human-il-1-racp-il-1-r3-his-avi-tag-protein-cf-binding-activity-2510202284833.jpg)
![SDS-Page IL-1 RAcP/IL-1 R3 [Biotin]](http://images.novusbio.com/fullsize/avi9176_recombinant-human-il-1-racp-il-1-r3-his-avi-tag-protein-cf-sds-page-2092022141122.jpg)
![Binding Activity IL-1 RAcP/IL-1 R3 [Unconjugated]](http://images.novusbio.com/images/11268-cp_recombinant-human-il-1-racp-il-1r3-st2-il-33r-fc-protein-cf-binding-activity-291120226466.jpg)
![SDS-Page IL-1 RAcP/IL-1 R3 [Unconjugated]](http://images.novusbio.com/fullsize/11268-cp_recombinant-human-il-1-racp-il-1r3-st2-il-33r-fc-protein-cf-sds-page-29920229339.jpg)
