Host: Mouse Monoclonal
Applications: WB, IP
Applications: Func, PAGE
Applications: B/N, Ctrl
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).
|Product By Gene ID
- interleukin-1 receptor accessory protein beta
- interleukin-1 receptor accessory protein
- IL-1 receptor accessory protein
- C3orf13IL-1RAcPIL1R3Interleukin-1 receptor 3
- interleukin 1 receptor accessory protein
Research Areas for IL-1 RAcP/IL-1 R3
Find related products by research area and learn more about each of the different research areas below.Cytokine ResearchImmunology
Bioinformatics Tool for IL-1 RAcP/IL-1 R3
Discover related pathways, diseases and genes to IL-1 RAcP/IL-1 R3. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.