Description
The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkappaBalpha and specifically phosphorylates IkappaBalpha on Serine 32 and 36, the sites that trigger its degradation. IKKalpha appears to be critical for NFkappaB activation in response to proinflammatory cytokines. Phosphorylation of IkappaB by IKKalpha is stimulated by the NFkappaB inducing kinase (NIK), which itself is a central regulator for NFkappaB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
1147 |
| Alternate Names |
- EC 2.7.11
- EC 2.7.11.10
- Nuclear factor NF-kappa-B inhibitor kinase alpha
- I-kappa-B kinase 1
- IkappaB kinase
- TCF16
- I-kappa-B kinase alpha
- TCF-16
- IKK-A
- Transcription factor 16
- Nuclear factor NFkappaB inhibitor kinase alpha
- IkBKA
- IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha
- NFKBIKAIKK-a kinase
- IKKAIkB kinase alpha subunit
- IKK1I-kappa-B kinase-alpha
- conserved helix-loop-helix ubiquitous kinaseIKBKA
|
Bioinformatics Tool for IKK alpha/beta
Discover related pathways, diseases and genes to IKK alpha/beta. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.
