IKK alpha/beta Products

Description

The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha) interacts with IkappaB-alpha and specifically phosphorylates IkappaB-alpha on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, designated IKKalpha, IKKbeta and IKKgamma (also designated NEMO); each appears to make essential contributions to IkappaB phosphorylation. NFkappaB inducing kinase (NIK) phosphorylates IKKalpha at Serine 176.

Bioinformatics

Entrez	1147 Human 12675 Mouse 309361 Rat
Product By Gene ID	1147
Alternate Names	conserved helix-loop-helix ubiquitous kinaseIKBKA EC 2.7.11 EC 2.7.11.10 I-kappa-B kinase 1 I-kappa-B kinase alpha IkappaB kinase IkBKA IKK1I-kappa-B kinase-alpha IKK-A IKKAIkB kinase alpha subunit IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha NFKBIKAIKK-a kinase Nuclear factor NFkappaB inhibitor kinase alpha Nuclear factor NF-kappa-B inhibitor kinase alpha TCF16 TCF-16 Transcription factor 16

Research Areas for IKK alpha/beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
DNA replication, Transcription, Translation and Splicing
Immunology
Innate Immunity
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction