IKK alpha/beta Products

Description

The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkappaBalpha and specifically phosphorylates IkappaBalpha on Serine 32 and 36, the sites that trigger its degradation. IKKalpha appears to be critical for NFkappaB activation in response to proinflammatory cytokines. Phosphorylation of IkappaB by IKKalpha is stimulated by the NFkappaB inducing kinase (NIK), which itself is a central regulator for NFkappaB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation.

Bioinformatics

Entrez	1147 Human 12675 Mouse 309361 Rat
Uniprot	O15111 Human O15111/ O14920 Human
Product By Gene ID	1147
Alternate Names	conserved helix-loop-helix ubiquitous kinaseIKBKA EC 2.7.11 EC 2.7.11.10 I-kappa-B kinase 1 I-kappa-B kinase alpha IkappaB kinase IkBKA IKK1I-kappa-B kinase-alpha IKK-A IKKAIkB kinase alpha subunit IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha NFKBIKAIKK-a kinase Nuclear factor NFkappaB inhibitor kinase alpha Nuclear factor NF-kappa-B inhibitor kinase alpha TCF16 TCF-16 Transcription factor 16

Research Areas for IKK alpha/beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
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DNA replication, Transcription, Translation and Splicing
Immunology
Innate Immunity
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction