IKK alpha/beta Research Products: Novus Biologicals

IKK alpha/beta Antibody (1)

Antibodies

IKK alpha/beta Antibody (SN06 ...

NBP2-67651

Immunocytochemistry/Immunofluorescence IKK alpha/beta Antibody (SN06-99)

Immunohistochemistry-Paraffin IKK alpha/beta Antibody (SN06-99)

Flow Cytometry IKK alpha/beta Antibody (SN06-99)

Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal

Description

The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkappaBalpha and specifically phosphorylates IkappaBalpha on Serine 32 and 36, the sites that trigger its degradation. IKKalpha appears to be critical for NFkappaB activation in response to proinflammatory cytokines. Phosphorylation of IkappaB by IKKalpha is stimulated by the NFkappaB inducing kinase (NIK), which itself is a central regulator for NFkappaB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation.

Bioinformatics

Entrez	1147 Human 12675 Mouse 309361 Rat
Uniprot	O15111 Human O15111/ O14920 Human
Product By Gene ID	1147
Alternate Names	EC 2.7.11 EC 2.7.11.10 Nuclear factor NF-kappa-B inhibitor kinase alpha I-kappa-B kinase 1 IkappaB kinase TCF16 I-kappa-B kinase alpha TCF-16 IKK-A Transcription factor 16 Nuclear factor NFkappaB inhibitor kinase alpha IkBKA IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha NFKBIKAIKK-a kinase IKKAIkB kinase alpha subunit IKK1I-kappa-B kinase-alpha conserved helix-loop-helix ubiquitous kinaseIKBKA