IgE Fc Products

Description

IgE is an immunoglobulin that plays a critical role in the immune response to parasitic infections and in the development of allergic reactions. Like other antibody classes, IgE has the same molecular architecture that includes two heavy chains and two light chains, but its heavy chain contains an additional domain compared to IgG heavy chain. IgE binds to its receptor, Fc epsilon RI, on the surface of mast cells and basophils, triggering the release of histamine and other mediators that cause the symptoms of allergic reactions (1, 2). The recombinant human IgE-Fc protein is a valuable tool for researchers studying the mechanisms of allergic reactions and the development of new therapies for allergic diseases. It can be used in a wide range of applications, including ELISA assays, Western blotting, functional assays to study the binding of IgE to its receptor, Fc epsilon RI, and the downstream signaling pathways that are activated upon binding (1, 2, 3). In addition to its research applications, the recombinant human IgE-Fc protein has potential therapeutic applications in the treatment of allergic diseases. Therapies that target IgE have been shown to be effective in the treatment of allergic diseases such as asthma and atopic dermatitis (4).

Bioinformatics

Uniprot	P01854-1
Product By Gene ID	9835
Alternate Names	constant region of heavy chain of IgE IgE Fc immunoglobulin epsilon immunoglobulin heavy constant epsilon