IFN-alpha K Products

Description

Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors (1). Human IFNA2 was originally cloned in the early ‘80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology (2-4). Structurally, type I IFNs belong to the class of five helical‑bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds (5). Mature human IFNA6, also known as IFN-alpha K, shares 56% aa sequence identity with mouse IFNA6. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) (6, 7). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA6 has been shown to be a strong inducer of IFN-stimulated genes and anti-viral protection (8). IFNA6 displays high potency against metapneumovirus and inhibition of HIV infection (9).

Bioinformatics

Uniprot	P05013.1
Product By Gene ID	3443
Alternate Names	IFNA6 IFN-alpha 6 IFNalpha K IFN-alpha K IFN-kappa interferon kappa interferon, kappa RP11-27J8.1 UNQ6124/PRO20084