HUS1B Products

Description

HUS1B is encoded by the Hus1B gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the checkpoint protein RAD1 but not with RAD9. Over expression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to HUS1. Hus1B is expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.

Bioinformatics

Uniprot	Q8NHY5 Human
Product By Gene ID	135458
Alternate Names	checkpoint protein HUS1B hHUS1B HUS1 (S. pombe) checkpoint homolog b HUS1 checkpoint homolog b (S. pombe) MGC126746 MGC126748 RP11-532F6.1

Diseases related to HUS1B

Discover more about diseases related to HUS1B.

Neoplasms
Malignant Neoplasms
Cardiomyopathy, Familial Idiopathic
Testicular Neoplasms
Malignant Neoplasm Of Breast
Seminoma
Neoplasms, Glandular And Epithelial
Ataxia Telangiectasia
Leukemia
Acute Promyelocytic Leukemia
Polyposis
Mammary Neoplasms
Stomach Diseases
Colorectal Cancer
Cytogenetic Abnormality
Genotoxic Stress
Ovarian Neoplasm
Sporadic Breast Carcinoma

Pathways for HUS1B

View related products by pathway and learn more about each of the pathways below.

Cell Cycle
Cell Cycle Checkpoint
Dna Repair
Dna Replication
Dna Damage Checkpoint
Cell Cycle Arrest
Mismatch Repair
Cell Death
Cell Proliferation
Induction Of Apoptosis
Dna Recombination
Localization
Apoptotic Dna Fragmentation
Telomere Maintenance

PTMs for HUS1B

Learn more about PTMs related to HUS1B.

Phosphorylation
Reduction
Deamination
Acetylation
Methylation

Bioinformatics Tool for HUS1B

Discover related pathways, diseases and genes to HUS1B. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.