WB, ChIP, ELISA, ICC/IFHost:
hpl-2 encodes one of two C. elegans heterochromatin protein 1 (HP1) homologs; hpl-2 activity is required for silencing of transgenes in the germline, germline development, and vulval cell fate specification; in addition, hpl-2 negatively regulates RNA-mediated interference (RNAi); hpl-2 also functions redundantly with hpl-1 in larval, somatic gonad and germline development, and redundantly with hpl-1, lin-13, lin-15A, lin-9, and lin-35 in vulval development; HPL-2 reporter fusion proteins are expressed in nuclei throughout the life cycle with expression also seen in the germline and developing oocytes; in nuclei, HPL-2 fusion proteins are associated with condensed chromatin; HPL-2::RFP foci do not significantly overlap with those of HPL-1.
- HP1 Like (heterochromatin protein)
Research Areas for HPL-2
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