HPL-2 Products


hpl-2 encodes one of two C. elegans heterochromatin protein 1 (HP1) homologs; hpl-2 activity is required for silencing of transgenes in the germline, germline development, and vulval cell fate specification; in addition, hpl-2 negatively regulates RNA-mediated interference (RNAi); hpl-2 also functions redundantly with hpl-1 in larval, somatic gonad and germline development, and redundantly with hpl-1, lin-13, lin-15A, lin-9, and lin-35 in vulval development; HPL-2 reporter fusion proteins are expressed in nuclei throughout the life cycle with expression also seen in the germline and developing oocytes; in nuclei, HPL-2 fusion proteins are associated with condensed chromatin; HPL-2::RFP foci do not significantly overlap with those of HPL-1.


Entrez C. elegans
Alternate Names
  • HP1 Like (heterochromatin protein)
  • HPL-2

Research Areas for HPL-2

Find related products by research area and learn more about each of the different research areas below.

modENCODE Antibodies